The Lab
At the University of Rijeka’s Department of Histology and Embryology, our lab investigates how the immune system can be shaped — not just by pathogens and molecules, but by experience itself.
We focus on the emerging concept that behavioral conditioning can modulate immune responses. By exploring how learned associations influence immune function, we aim to uncover novel mechanisms of immune regulation that could transform our understanding of inflammation, infection, and recovery.
Beyond conditioning, our research spans the intricate crosstalk between the nervous and immune systems in both health and disease. We study how neuroimmune interactions contribute to metabolic disorders, viral infections, and systemic inflammation — with a particular interest in how these systems co-adapt and co-regulate under stress, learning, and environmental change.
Our approach is interdisciplinary, combining:
· Neuroimmunology and behavioral science
· Advanced imaging
· Molecular and cellular immunology
· Animal models of disease and conditioning
We are driven by the belief that the immune system is not merely reactive — it is adaptive, trainable, and deeply integrated with the brain. Our goal is to map this integration and harness it for therapeutic insight.


About Me
marko.sestan@uniri.hr


I am an Associate Professor at the University of Rijeka, Department of Histology and Embryology, where I lead a research group dedicated to decoding the dynamic interplay between the nervous, immune, and endocrine systems. My scientific journey has consistently focused on how immune cells respond to and are shaped by their environment — in both health and disease.
During my PhD, I contributed to uncovering how viral infections can trigger immune-mediated mechanisms that lead to insulin resistance and type 2 diabetes mellitus. After earning my doctorate in 2018, I joined the Veiga-Fernandes group in Lisbon, Portugal, as a postdoctoral researcher, where I investigated neuro-immune circuits that regulate metabolic homeostasis.
In 2023, I returned to Croatia to establish my own lab, where we now explore how behavioral conditioning — the process by which organisms learn to associate stimuli with physiological responses — can modulate immune function. This emerging line of research aims to understand whether and how learned experiences can shape immune outcomes, with implications for infection, inflammation, and metabolic disease.
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+385 51 651 176
Contact
Faculty of Medicine
Department of histology & Embryology
Braće Branchetta 20
51000, Rijeka, Croatia

