Publications

Featured Publications

  • Šestan M, Mikašinović S, Benić A, Wueest S, Dimitropoulos C, Mladenić K, Krapić M, Hiršl L, Glantzspiegel Y, Rasteiro A, Alisezchik M, Cekinović Grbeša Đ, Turk Wensveen T, Babić M, Gat Viks I, Veiga-Fernandes H, Konrad D, Wensveen FM, Polić B, An IFNγ-dependent immune-endocrine circuit lowers blood glucose to potentiate the innate anti-viral immune response. Nat. Immunol. 2024 (Accepted)

  • Marinović S, Lenartić M, Mladenić K , Šestan, M, Kavazović I, Benić A, Krapić M, Rindlisbacher L, Cokarić Brdovčak M, Sparano C, Litscher G, Turk Wensveen T, Mikolasevic I, Fučkar Čupić D, Bilić-Zulle L, Steinle A, Waisman A, Hayday A, Tugues S, Becher B, Polić B, Wensveen FM, NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis, Science Immunology 2023 Sep 29;8(87):eadd1599

  • Jelenčić V, Šestan M, Kavazović I, Lenartić M, Marinović S, Holmes TD, Prchal-Murphy M, Lisnić B, Sexl V, Bryceson YT, Wensveen FM, Polić B. NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development. Nature Immunology. 2018 Oct;19(10):1083-1092.

  • Šestan M, Marinović S, Kavazović I, Cekinović Đ, Wueest S, Turk Wensveen T, Brizić I, Jonjić S, Konrad D, Wensveen FM, Polić B. Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity. Immunity. 2018 Jul 17;49(1):164-177.e6.

  • Wensveen FM, Jelenčić V, Valentić S, Šestan M, Wensveen TT, Theurich S, Glasner A, Mendrila D, Štimac D, Wunderlich FT, Brüning JC, Mandelboim O, Polić B. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nature Immunology. 2015 Apr;16(4):376-85.

  • Zafirova B, Mandarić S, Antulov R, Krmpotić A, Jonsson H, Yokoyama WM, Jonjić S, Polić B. Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice. Immunity. 2009 Aug 21;31(2):270-82.

Other Publications

  • Mladenić K, Lenartić M, Marinović S, Polić B, Wensveen FM. The "Domino effect" in MASLD: The inflammatory cascade of steatohepatitis. Eur J Immunol. 2024 Feb 5:e2149641. doi: 10.1002/eji.202149641.

  • Gašparini D, Wensveen FM, Turk Wensveen T. Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration Diabetes Res Clin Pract. 2023 Diabetes Res Clin Pract. 2024 Jan;207:111056. doi: 10.1016/j.diabres.2023.111056

  • Gašparini D, Zuljani A, Wensveen FM, Turk Wensveen T., A cross-sectional study in type 2 diabetes patients reveals that elevated pulse wave velocity predicts asymptomatic peripheral arterial disease associated with age and diabetes duration. Int J Cardiol Heart Vasc. 2023 Nov 26;49:101308. doi: 10.1016/j.ijcha.2023.101308

  • Marinović S, Lenartić M, Mladenić K , Šestan, M, Kavazović I, Benić A, Krapić M, Rindlisbacher L, Cokarić Brdovčak M, Sparano C, Litscher G, Turk Wensveen T, Mikolasevic I, Fučkar Čupić D, Bilić-Zulle L, Steinle A, Waisman A, Hayday A, Tugues S, Becher B, Polić B, Wensveen FM, NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis, Sci Immunol. 2023 Sep 29;8(87):eadd1599. doi: 10.1126/sciimmunol.add1599.

  • Imširović V, Lenartić M, Wensveen FM, Polić B, Jelenčić V. Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness. Front Immunol. 2023 Jul 13;14:1191884. doi: 10.3389/fimmu.2023.1191884.

  • Kavazović I, Dimitropoulos C, Gašparini D, Rončević Filipović M, Barković I, Koster J, Lemmermann NA, Babić M, Cekinović Grbeša Đ, Wensveen FM.,, Vaccination provides superior in vivo recall capacity of SARS-CoV-2-specific memory CD8 T cells. Cell Rep. 2023 Apr 4;42(4):112395. doi: 10.1016/j.celrep.2023.112395.

  • Martens AWJ, Kavazović I, Krapić M, Pack SM, Arens R, Jongejan A, Moerland PD, Eldering E, van der Windt GJW, Wensveen FM, Peters FS, Kater AP. Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors. Leukemia. 2023 Jan 19:1-11. doi: 10.1038/s41375-023-01817-z.

  • Benić A, Mikašinović S, Wensveen FM, Polić B,  Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver. Metabolites, 13 (2023), 2; 153. https://doi.org/10.3390/metabo1302015

  • Gašparini D, Kavazović I, Barković I, Maričić V, Ivaniš V, Samsa DT, Peršić V, Polić B, Turk Wensveen T, Wensveen FM., Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes. Immunol Lett. 2022 Aug;248:45-55. doi: 10.1016/j.imlet.2022.06.001.

  • Kavazović I, Krapić M, Beumer-Chuwonpad A, Polić B, Turk Wensveen T, Lemmermann NA, Van Gisbergen KPJM, Wensveen FM, Hyperglycemia and not hyperinsulinemia mediates diabetes-induced memory CD8 t cell dysfunction, Diabetes. 2022 Jan 14:db210209. doi: 10.2337/db21-0209.

  • Krapić M, Kavazović I, Wensveen FM. Immunological Mechanisms of Sickness Behavior in Viral Infection. Viruses. 2021 Nov 8;13(11):2245. doi: 10.3390/v13112245.

  • Parga-Vidal L, Behr FM, Kragten NAM, Nota B, Wesselink TH, Kavazović I, Covill LE, Schuller MBP, Bryceson YT, Wensveen FM, van Lier RAW, van Dam TJP, Stark R, van Gisbergen KPJM. Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes. Sci Immunol. 2021 Aug 20;6(62):eabg3533. doi: 10.1126/sciimmunol.abg3533.

  • Wensveen FM, Šestan M, Turk Wensveen T, Polić B. Blood glucose regulation in context of infection. Vitam Horm. 2021;117:253-318. doi: 10.1016/bs.vh.2021.06.009.

  • Turk Wensveen T, Gašparini D, Rahelić D, Wensveen FM, Type 2 diabetes and viral infection; cause and effect of disease. Diabetes Res Clin Pract. 2021 Feb;172:108637. DOI: 10.1016/j.diabres.2020.108637

  • Kavazović I, Han H, Balzaretti G, Slinger E, Lemmermann NAW, Ten Brinke A, Merkler D, Koster J, Bryceson Y, De Vries N, Jonjić S, Klarenbeek PL, Polić B, Eldering E, Wensveen FM, Eomes broadens the scope of CD8 T cell memory by inhibiting apoptosis in cells of low affinity. PLoS Biol. 2020 Mar 17;18(3):e3000648. DOI: 10.1371/journal.pbio.3000648

  • Turk Wensveen T, Fučkar Ćupić D, Jurišić Eržen D, Polić B, Wensveen FM, Severe lipoatrophy in a patient with diabetes mellitus type 2 in response to glargine and degludec insulin: Possible involvement of CD4 T cell mediated tissue remodelling. Diabetes Care. 2020 Feb;43(2):494-496. doi: 10.2337/dc19-1888.

  • Wensveen FM, Šestan M, Turk Wensveen T, Polić B., 'Beauty and the beast' in infection: How immune-endocrine interactions regulate systemic metabolism in the context of infection. Eur J Immunol. 2019 Jul;49(7):982-995. doi: 10.1002/eji.201847895.

  • Grčević D, Šućur A, Wensveen F., Croatian Immunological Society: Our half century. Eur J Immunol. 2019 Feb;49(2):208-211. doi: 10.1002/eji.201970025.

  • Kavazović I, Polić B, Wensveen FM, Cheating the hunger games; Mechanisms controlling clonal diversity of CD8 effector and memory populations. Front Immunol. 2018 Nov 29;9:2831. doi: 10.3389/fimmu.2018.02831

  • Jelenčić V, Šestan M, Kavazović I, Lenartić M, Marinović S, Holmes TD, Prchal-Murphy M, Lisnić B, Sexl V, Bryceson YT, Wensveen FM, Polić B. NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development. Nat Immunol. 2018 Oct;19(10):1083-1092. doi: 10.1038/s41590-018-0209-9.

  • Šestan M, Marinović S, Kavazović I, Cekinović Đ, Wueest S, Turk Wensveen T, Brizić I, Jonjić S, Konrad D, Wensveen FM, Polić B. Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity. Immunity. 2018 Jul 17;49(1):164-177.e6. doi: 10.1016/j.immuni.2018.05.005.

  • Wensveen FM, Jelenčić V, Polić B. NKG2D: A Master Regulator of Immune Cell Responsiveness. Front Immunol. 2018 Mar 8;9:441. doi: 10.3389/fimmu.2018.00441.

  • Jelenčić V, Lenartić M, Wensveen FM, Polić B, NKG2D: A versatile player in the immune system. Immunol Lett. 2017 Sep;189:48-53. doi: 10.1016/j.imlet.2017.04.006.

  • Kavazović I, Lenartić M, Jelenčić V, Jurković S, Lemmermann NAW, Jonjić S, Polić B, Wensveen FM, NKG2D stimulation of CD8+ T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice. Eur J Immunol. 2017 Jul;47(7):1123-1135. doi: 10.1002/eji.201646805.

  • Lenartić M, Jelenčić V, Zafirova B, Ožanič M, Marečić V, Jurković S, Sexl V, Šantić M, Wensveen FM, Polić B. NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection. J Immunol. 2017 Jan 13. pii: 1600461. doi: 10.4049/jimmunol.1600461.

  • Mikolasevic I, Milic S, Turk Wensveen T, Grgic I, Jakopcic I, Stimac D, Wensveen F, Orlic L. Nonalcoholic fatty liver disease - A multisystem disease? World J Gastroenterol. 2016 Nov 21;22(43):9488-9505. Review. DOI: 10.3748/wjg.v22.i43.9488

  • Wensveen FM, Slinger E, van Attekum MH, Brink R, Eldering E. Antigen-affinity controls pre-germinal center B cell selection by promoting Mcl-1 induction through BAFF receptor signaling. Sci Rep. 2016 Oct 20;6:35673. doi: 10.1038/srep35673.

  • Slinger E, Wensveen FM, Guikema JE, Kater AP, Eldering E. Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA. Haematologica. 2016 Sep;101(9):e374-7. doi: 10.3324/haematol.2016.142323. PubMed PMID: 27479816; DOI: 10.3324/haematol.2016.142323

  • Sagiv A, Burton DG, Moshayev Z, Vadai E, Wensveen F, Ben-Dor S, Golani O, Polic B, Krizhanovsky V. NKG2D ligands mediate immunosurveillance of senescent cells. Aging (Albany NY). 2016 Feb;8(2):328-44. DOI: 10.18632/aging.100897

  • Wensveen FM, Valentić S, Šestan M, Turk Wensveen T, Polić B. The "Big Bang" in obese fat: Events initiating obesity-induced adipose tissue inflammation. Eur J Immunol. 2015 Sep;45(9):2446-56. doi: 10.1002/eji.201545502.

  • Wensveen FM, Valentić S, Šestan M, Wensveen TT, Polić B. Interactions between adipose tissue and the immune system in health and malnutrition. Semin Immunol. 2015 Sep;27(5):322-33. doi: 10.1016/j.smim.2015.10.006. Review.

  • Wensveen FM, Jelenčić V, Valentić S, Šestan M, Wensveen TT, Theurich S, Glasner A, Mendrila D, Štimac D, Wunderlich FT, Brüning JC, Mandelboim O, Polić B. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015 Apr;16(4):376-85. doi: 10.1038/ni.3120.

  • Wensveen FM, Geest CR, Libregts SF, Derks IA, Ekert PG, Labi V, Villunger A,  Nolte MA, Eldering E. BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis. Apoptosis. 2013 Nov;18(11):1306-18. doi: 10.1007/s10495-013-0890-y.

  • Trsan T, Busche A, Abram M, Wensveen FM, Lemmermann NA, Arapovic M, Babic M, Tomic A, Golemac M, Brinkmann MM, Jäger W, Oxenius A, Polic B, Krmpotic A, Messerle M, Jonjic S. Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16550-5. doi: 0.1073/pnas.1310215110.

  • Wensveen FM, Lenartic M, Jelencic V, Lemmermann NA, ten Brinke A, Jonjic S, Polic B. NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase. J Immunol. 2013 Augv1;191(3):1307-15. doi: 10.4049/jimmunol.1300670.

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Faculty of Medicine

Department of histology & Embryology

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