Marko Šestan publishes new groundbreaking study in Science

Marko Šestan publishes groundbreaking study that discovers a new mechanism that regulates blood glucose

Recent advancements in science reveal profound insights into how our body regulates vital nutrients, specifically blood glucose levels. Traditionally, it was believed that this process was predominantly managed by the endocrine system. However, a groundbreaking study led by Marko Šestan and published in Science Magazine challenges these long-standing beliefs.

A New Perspective: Immune Cells in Blood Glucose Regulation

In his research conducted under the guidance of Henrique Veiga-Fernandes, Marko identified a new immune-neuro-endocrine loop that plays a significant role in modulating blood glucose levels during fasting. This discovery highlights the function of immune cells, showing that they serve as a vital link between the nervous and endocrine systems. The ability of our body to maintain serum concentrations of nutrients, such as glucose, is crucial not just when food is plentiful but also during periods of fasting.

Implications of the Findings

The findings from Marko's study signify a paradigm shift in our understanding of glucose metabolism. By recognizing the contribution of immune cells to blood glucose regulation, it opens avenues for new therapeutic strategies aimed at disorders like diabetes. This integrated approach underscores the intricate dance between various systems in maintaining homeostasis in the body.

Overall, the study sheds light on the complex interactions between the immune system, the nervous system, and endocrine pathways, reinforcing the notion that regulation mechanisms are far more intricate than previously acknowledged. As research in this area advances, we may uncover additional layers of complexity that could lead to innovative treatments and a deeper understanding of metabolic diseases.

Read the article in full here:

Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis | Science